Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ANO5 ensures trafficking of annexins in wounded myofibers.

The Journal of cell biology - 1 Mar 2021

Foltz Steven J, Cui Yuan Yuan, Choo Hyojung J, Hartzell H Criss

Abstract excerpt

Mutations in ANO5 (TMEM16E) cause limb-girdle muscular dystrophy R12. Defective plasma membrane repair is a likely mechanism. Using myofibers from Ano5 knockout mice, we show that trafficking of several annexin proteins, which together form a cap at the site of injury, is altered upon loss of ANO5. Annexin A2 accumulates at the wound to nearly twice the level observed in WT fibers, while annexin A6 accumulation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Annexins
Share to Anoctamins
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Fibers, Skeletal

Share to Phosphatidylethanolamines

Share to Phosphatidylserines

Share to Protein Domains

Share to Protein Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 33496727
DOI: 10.1083/jcb.202007059
PMCID: PMC7844426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ANO5 ensures trafficking of annexins in wounded myofibers.PMID 33496727Read ↗

Defective Trafficking of Annexins to the Site of Injury in ANO5-Knockout Muscle FibersSemantic proximity Read ↗

Defective membrane fusion and repair in Anoctamin5-deficient muscular dystrophy.Semantic proximity Read ↗

Membrane repair of human skeletal muscle cells requires Annexin-A5.Semantic proximity Read ↗

Recombinant annexin A6 promotes membrane repair and protects against muscle injurySemantic proximity Read ↗

Annexin A6 modifies muscular dystrophy by mediating sarcolemmal repair.Semantic proximity Read ↗

Trafficking of Annexins during Membrane Repair in Human Skeletal Muscle CellsSemantic proximity Read ↗

Duchenne muscular dystrophy is driven by defective membrane repair and annexin-A2 dysregulation in skeletal muscleSemantic proximity Read ↗

Anoctamin 5 Knockout Mouse Model Recapitulates LGMD2L Muscle Pathology and Offers Insight Into in vivo Functional Deficits.Semantic proximity Read ↗

Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing.Semantic proximity Read ↗

Enhanced Muscular Dystrophy from Loss of Dysferlin Is Accompanied by Impaired Annexin A6 Translocation after Sarcolemmal Disruption.Semantic proximity Read ↗

Sorcin couples Annexin A11 recruitment to ESCRT-III assembly for plasma membrane repairSemantic proximity Read ↗

The phenotype of dysferlin-deficient mice is not rescued by adeno-associated virus-mediated transfer of anoctamin 5.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.