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Histone deacetylase 6 (HDAC6) is an essential factor for oocyte maturation and asymmetric division in mice

8 Aug 2017

Abstract excerpt

Tubastatin A (Tub-A), a highly selective histone deacetylase 6 (HDAC6) inhibitor, has been widely used as a cytotoxic anticancer agent, or for the treatment of patients with asthma. However, the potential toxicity of Tub-A on oocyte maturation and asymmetric division is still unclear. Therefore, the present study was designed to examine the effect and potential regulatory role of Tub-A on the meiotic maturation...

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PMID: 28811599
DOI: 10.1038/s41598-017-08650-2

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