Article
Motor coordination, exploration, and spatial learning in a natural mouse mutation (nervous) with Purkinje cell degeneration.
Behavior genetics - 1 Jan 2003
Lalonde R, Strazielle C
Abstract excerpt
The nervous mouse mutation causes a relatively selective degeneration of Purkinje cells in the cerebellar cortex. The mutants were compared to age-matched controls of the same background strain in tests of motor activity and coordination, spontaneous alternation, and spatial learning in the Morris water maze. As expected from their ataxia, the nervous mutants were impaired in stationary beam, coat-hanger, and...
Topics
- Analysis of Variance
- Animals
- Behavior, Animal
- Body Weight
- Case-Control Studies
- Cerebellum
- Exploratory Behavior
- Female
- Maze Learning
- Mice
- Mice, Inbred C3H
- Mice, Neurologic Mutants
- Motor Activity
- Nerve Degeneration
- Phenotype
- Psychomotor Performance
- Purkinje Cells