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Article

Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets

16 Oct 2015

Abstract excerpt

AIMS/HYPOTHESIS: Ageing can lead to reduced insulin sensitivity and loss of pancreatic beta cell function, predisposing individuals to the development of diabetes. The aim of this study was to assess the contribution of microRNAs (miRNAs) to age-associated beta cell dysfunction. METHODS: The global mRNA and miRNA profiles of 3- and 12-month-old rat islets were collected by microarray. The functional impact of...

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PMID: 26474776
DOI: 10.1007/s00125-015-3783-5

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