Article
Identification of an Association of TNFAIP3 Polymorphisms With Matrix Metalloproteinase Expression in Fibroblasts in an Integrative Study of Systemic Sclerosis-Associated Genetic and Environmental Factors.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Mar 2016
Wei Peng, Yang Yang, Guo Xinjian, Hei Nainan, Lai Syeling, Assassi Shervin, Liu Mengyuan, Tan Filemon, Zhou Xiaodong
Abstract excerpt
OBJECTIVE: Systemic sclerosis (SSc) is a fibrotic disease attributed to both genetic susceptibility and environmental factors. This study was undertaken to investigate the associations between SSc-associated genetic variants and the expression of extracellular matrix (ECM) genes in human fibroblasts stimulated with silica particles in time-course and dose-response experiments. METHODS: A total of 200 fibroblast...
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