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Discovery and characterization of natural tropolones as inhibitors of the antibacterial target CapF from Staphylococcus aureus

16 Oct 2015

Abstract excerpt

The rapid spread of antibiotic-resistance among pathogenic bacteria poses a serious risk for public health. The search for novel therapeutic strategies and antimicrobial compounds is needed to ameliorate this menace. The bifunctional metalloenzyme CapF is an antibacterial target produced by certain pathogenic bacteria essential in the biosynthetic route of capsular polysaccharide, a mucous layer on the surface of...

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PMID: 26471247
DOI: 10.1038/srep15337

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