Article
Combinatorial phenotypic screen uncovers unrecognized family of extended thiourea inhibitors with copper-dependent anti-staphylococcal activity.
Metallomics : integrated biometal science - 1 Apr 2016
Dalecki Alex G, Malalasekera Aruni P, Schaaf Kaitlyn, Kutsch Olaf, Bossmann Stefan H, Wolschendorf Frank
Abstract excerpt
The continuous rise of multi-drug resistant pathogenic bacteria has become a significant challenge for the health care system. In particular, novel drugs to treat infections of methicillin-resistant Staphylococcus aureus strains (MRSA) are needed, but traditional drug discovery campaigns have largely failed to deliver clinically suitable antibiotics. More than simply new drugs, new drug discovery approaches are...
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