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From Microbes to Medicine: Targeting Metalloprotein Pathways for Innovative Antibacterial Strategies

2025-12-18

Abstract excerpt

Antibiotic resistance poses a growing global health crisis, demanding innovative therapeutic strategies beyond traditional drug classes. This review hypothesizes that selective targeting of bacterial metalloprotein pathways—particularly siderophore-mediated iron acquisition and manganese-dependent oxidative defense—offers the most promising route to narrow-spectrum antibacterial agents with reduced host toxicity....

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Literature Corpus work
ddcde7a8-d73a-5e86-8674-14239bf76c32
DOI
10.20944/preprints202512.1598.v1
Open publication

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