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Article

Discovery and characterization of an antibody directed against exosite I of thrombin.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2016

Baglin T P, Langdown J, Frasson R, Huntington J A

Abstract excerpt

UNLABELLED: ESSENTIALS: An IgA paraprotein with anti-thrombin activity was not associated with a severe bleeding phenotype. This observation challenges the paradigm that anticoagulant therapy necessarily increases bleeding risk. Characterization of the antibody showed that it specifically binds to thrombin exosite I. A therapeutic drug with the properties of this antibody might be an antithrombotic that doesn't...

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Source

Identifiers

PMID: 26469093
DOI: 10.1111/jth.13171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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