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Article

Natural history of antiplatelet antibody formation in patients with Glanzmann thrombasthenia: a French multicenter prospective study.

Journal of thrombosis and haemostasis : JTH - 1 Jul 2026

Desprez Dominique, d'Oiron Roseline, Voisin Sophie, Falaise Céline, Alessi Marie-Christine, Saultier Paul, Lavigne Géraldine, Essaydi Arnaud, Apithy Marie-Joelle, Dupuis Arnaud, Goin Valérie, Huguenin Yoann, Fiore Mathieu

Abstract excerpt

BACKGROUND: Glanzmann thrombasthenia (GT) is a rare inherited platelet function disorder caused by defects in the ITGA2B or ITGB3 genes encoding the αIIbβ3 integrin. Repeated transfusions often lead to immunization against αIIbβ3 and/or HLA antigens, compromising transfusion efficacy. OBJECTIVES: This study aimed to prospectively characterize the development and evolution of anti-αIIbβ3 and anti-HLA antibodies in...

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Source

Identifiers

PMID: 42025768
DOI: 10.1016/j.jtha.2026.03.024

Genes

ITGA2B
ITGB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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Natural history of antiplatelet antibody formation in patients with Glanzmann thrombasthenia: a French multicenter prospective study.PMID 42025768Read ↗

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