Article
Epigenetic Alterations in Fanconi Anaemia: Role in Pathophysiology and Therapeutic Potential.
PloS one - 1 Jan 2015
Belo Hélio, Silva Gabriela, Cardoso Bruno A, Porto Beatriz, Minguillon Jordi, Barbot José, Coutinho Jorge, Casado Jose A, Benedito Manuela, Saturnino Hema, Costa Emília, Bueren Juan A, Surralles Jordi, Almeida Antonio
Abstract excerpt
Fanconi anaemia (FA) is an inherited disorder characterized by chromosomal instability. The phenotype is variable, which raises the possibility that it may be affected by other factors, such as epigenetic modifications. These play an important role in oncogenesis and may be pharmacologically manipulated. Our aim was to explore whether the epigenetic profiles in FA differ from non-FA individuals and whether these...
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