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Thymosin beta 4 up‐regulates miR‐200a expression and induces differentiation and survival of rat brain progenitor cells

14 Oct 2015

Abstract excerpt

Thymosin beta 4 (Tβ4), a secreted 43 amino acid peptide, promotes oligodendrogenesis, and improves neurological outcome in rat models of neurologic injury. We demonstrated that exogenous Tβ4 treatment up-regulated the expression of the miR-200a in vitro in rat brain progenitor cells and in vivo in the peri-infarct area of rats subjected to middle cerebral artery occlusion (MCAO). The up-regulation of miR-200a...

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PMID: 26466330
DOI: 10.1111/jnc.13394

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