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Article

BET bromodomain inhibition promotes neurogenesis while inhibiting gliogenesis in neural progenitor cells.

Stem cell research - 1 Sept 2016

Li Jingjun, Ma Jing, Meng Guofeng, Lin Hong, Wu Sharon, Wang Jamie, Luo Jie, Xu Xiaohong, Tough David, Lindon Matthew, Rioja Inmaculada, Zhao Jing, Mei Hongkang, Prinjha Rab, Zhong Zhong

Abstract excerpt

Neural stem cells and progenitor cells (NPCs) are increasingly appreciated to hold great promise for regenerative medicine to treat CNS injuries and neurodegenerative diseases. However, evidence for effective stimulation of neuronal production from endogenous or transplanted NPCs for neuron replacement with small molecules remains limited. To identify novel chemical entities/targets for neurogenesis, we had...

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PMID: 27591477
DOI: 10.1016/j.scr.2016.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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