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Changes in DNA methylation are associated with the development of drug resistance in cervical cancer cells

13 Oct 2015

Abstract excerpt

BACKGROUND AND PROPOSE: Changes in DNA methylation are associated with changes in somatic cell fate without the alteration of coding sequences. In addition to its use as a traceable biomarker, reversible DNA methylation could also serve as a therapeutic target. In particular, if the development of drug resistance is associated with changes in DNA methylation, then demethylation might reverse the resistance...

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PMID: 26464562
DOI: 10.1186/s12935-015-0248-3

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