Article

Abnormal genome-wide DNA methylation induced by cisplatin may contribute to the chemo-resistance of human small cell lung cancer

2019-12-11

Abstract excerpt

<title>Abstract</title> <p>Background: So far, the platinum-based chemotherapy (e.g. cisplatin-etoposide doublet) is still the backbone for SCLC management due to its high respond rate both in LS-SCLC and ES-SCLC. However, cisplatin treatment often results in the development of chemo-resistance, leading to therapeutic failure and becoming the main obstacle to improve the therapeutic efficacy. Currently, little ha...

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Literature Corpus work: 7a69292e-5850-52e4-94e3-7f03419a5351
DOI: 10.21203/rs.2.18626/v1

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