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Article

Monocytes/macrophages activation contributes to b-gamma-glutamyltransferase accumulation inside atherosclerotic plaques.

Journal of translational medicine - 13 Oct 2015

Belcastro Eugenia, Franzini Maria, Cianchetti Silvana, Lorenzini Evelina, Masotti Silvia, Fierabracci Vanna, Pucci Angela, Pompella Alfonso, Corti Alessandro

Abstract excerpt

BACKGROUND: Gamma-glutamyltransferase (GGT) is a well-established independent risk factor for cardiovascular mortality related to atherosclerotic disease. Four GGT fractions have been identified in plasma, but only b-GGT fraction accumulates in atherosclerotic plaques, and correlates with other histological markers of vulnerability. The present study was aimed to evaluate whether macrophagic lineage cells may...

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Source

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Identifiers

PMID: 26463174
DOI: 10.1186/s12967-015-0687-6
PMCID: PMC4604102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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