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Article

CD163+ macrophages are associated with a vulnerable plaque phenotype in human carotid plaques.

Scientific reports - 1 Sept 2020

Bengtsson Eva, Hultman Karin, Edsfeldt Andreas, Persson Ana, Nitulescu Mihaela, Nilsson Jan, Gonçalves Isabel, Björkbacka Harry

Abstract excerpt

Macrophages are a functionally heterogeneous group of immune cells abundant in atherosclerotic plaques. Macrophages expressing CD163 are associated with intraplaque hemorrhage and have previously been considered atheroprotective. However, in a recent study CD163-deficient atherosclerotic ApoE-/- mice exhibited smaller and less complex plaques, suggesting a proatherogenic role of CD163. Previous smaller studies on...

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Share to Antigens, CD

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Differentiation, Myelomonocytic

Share to Carotid Arteries

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Share to CD163 Antigen

Share to Plaque, Atherosclerotic

Share to Receptors, Cell Surface

Source

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Identifiers

PMID: 32873809
DOI: 10.1038/s41598-020-71110-x
PMCID: PMC7463157

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