Article
Serum progranulin irrelated with Breg cell levels, but elevated in RA patients, reflecting high disease activity.
Rheumatology international - 1 Mar 2016
Chen Jiaxi, Li Shuang, Shi Jianfeng, Zhang Lili, Li Jun, Chen Shiyong, Wu Chunlong, Shen Bo
Abstract excerpt
Soluble progranulin (PGRN) is known to directly regulate regulatory T cells; however, whether PGRN levels are elevated in patients with rheumatoid arthritis and affect the regulatory subsets of B cells remain unknown. In this study, a total of 80 RA patients and 60 healthy controls were studied. Serum progranulin levels were determined using enzyme-linked immune-sorbent assay. A receiver operating characteristic...
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