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Article

Pharmacokinetics of metoprolol during pregnancy and lactation.

Journal of clinical pharmacology - 1 May 2016

Ryu Rachel J, Eyal Sara, Easterling Thomas R, Caritis Steve N, Venkataraman Raman, Hankins Gary, Rytting Erik, Thummel Kenneth, Kelly Edward J, Risler Linda, Phillips Brian, Honaker Matthew T, Shen Danny D, Hebert Mary F

Abstract excerpt

The objective of this study was to evaluate the steady-state pharmacokinetics of metoprolol during pregnancy and lactation. Serial plasma, urine, and breast milk concentrations of metoprolol and its metabolite, α-hydroxymetoprolol, were measured over 1 dosing interval in women treated with metoprolol (25-750 mg/day) during early pregnancy (n = 4), mid-pregnancy (n = 14), and late pregnancy (n = 15), as well as...

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Share to Adrenergic beta-Antagonists
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Identifiers

PMID: 26461463
DOI: 10.1002/jcph.631
PMCID: PMC5564514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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