Article
Pharmacokinetics of metformin during pregnancy.
Drug metabolism and disposition: the biological fate of chemicals - 1 May 2010
Eyal Sara, Easterling Thomas R, Carr Darcy, Umans Jason G, Miodovnik Menachem, Hankins Gary D V, Clark Shannon M, Risler Linda, Wang Joanne, Kelly Edward J, Shen Danny D, Hebert Mary F
Abstract excerpt
Our objective was to evaluate the pharmacokinetics of metformin during pregnancy. Serial blood and urine samples were collected over one steady-state dosing interval in women treated with metformin during early to late pregnancy (n = 35) and postpartum (n = 16). Maternal and umbilical cord blood...
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