Article
Noninvasive monitoring of infection and rejection after lung transplantation.
Proceedings of the National Academy of Sciences of the United States of America - 27 Oct 2015
De Vlaminck Iwijn, Martin Lance, Kertesz Michael, Patel Kapil, Kowarsky Mark, Strehl Calvin, Cohen Garrett, Luikart Helen, Neff Norma F, Okamoto Jennifer, Nicolls Mark R, Cornfield David, Weill David, Valantine Hannah, Khush Kiran K, Quake Stephen R
Abstract excerpt
The survival rate following lung transplantation is among the lowest of all solid-organ transplants, and current diagnostic tests often fail to distinguish between infection and rejection, the two primary posttransplant clinical complications. We describe a diagnostic assay that simultaneously monitors for rejection and infection in lung transplant recipients by sequencing of cell-free DNA (cfDNA) in plasma. We...
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