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Article

Validation of a Clinical-Grade Assay to Measure Donor-Derived Cell-Free DNA in Solid Organ Transplant Recipients.

The Journal of molecular diagnostics : JMD - 1 Nov 2016

Grskovic Marica, Hiller David J, Eubank Lane A, Sninsky John J, Christopherson Cindy, Collins John P, Thompson Kathryn, Song Mindy, Wang Yue S, Ross David, Nelles Mitchell J, Yee James P, Wilber Judith C, Crespo-Leiro Maria G, Scott Susan L, Woodward Robert N

Abstract excerpt

The use of circulating cell-free DNA (cfDNA) as a biomarker in transplant recipients offers advantages over invasive tissue biopsy as a quantitative measure for detection of transplant rejection and immunosuppression optimization. However, the fraction of donor-derived cfDNA (dd-cfDNA) in transplant recipient plasma is low and challenging to quantify. Previously reported methods to measure dd-cfDNA require donor...

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Identifiers

PMID: 27727019
DOI: 10.1016/j.jmoldx.2016.07.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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