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Circulating Cell-Free DNA Enables Noninvasive Diagnosis of Heart Transplant Rejection

18 Jun 2014

Abstract excerpt

Monitoring allograft health is an important component of posttransplant therapy. Endomyocardial biopsy is the current gold standard for cardiac allograft monitoring but is an expensive and invasive procedure. Proof of principle of a universal, noninvasive diagnostic method based on high-throughput screening of circulating cell-free donor-derived DNA (cfdDNA) was recently demonstrated in a small retrospective...

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PMID: 24944192
DOI: 10.1126/scitranslmed.3007803

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