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Absolute quantification of donor-derived cell-free DNA following pediatric and adult heart transplantation

8 May 2025

Abstract excerpt

OBJECTIVE: Traditional rejection surveillance after heart transplantation (HTx) is based on endomyocardial biopsies (EMBs), which are invasive, expensive, and associated with complications. Monitoring using cell-free DNA (cfDNA) is promising, but most studies report only on the donor fraction (DF) as the percentage of donor-derived cfDNA (dd-cfDNA) relative to total cfDNA. We evaluated the performance of dd-cfDNA...

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PMID: 40345563
DOI: 10.1016/j.healun.2025.04.024

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