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A novel donor-derived cell-free DNA assay for the detection of acute rejection in heart transplantation

10 Apr 2022

Abstract excerpt

BACKGROUND: Endomyocardial biopsy (EMB), the reference surveillance test for acute rejection (AR) in heart transplant (HTx) recipients, is invasive, costly, and shows significant interobserver variability. Recent studies indicate that donor-derived cell-free DNA (dd-cfDNA), obtained non-invasively from blood, is associated with AR and could reduce the frequency of EMB surveillance. The aim of this study was to...

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PMID: 35577713
DOI: 10.1016/j.healun.2022.04.002

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