Article
Universal noninvasive detection of solid organ transplant rejection.
Proceedings of the National Academy of Sciences of the United States of America - 12 Apr 2011
Snyder Thomas M, Khush Kiran K, Valantine Hannah A, Quake Stephen R
Abstract excerpt
It is challenging to monitor the health of transplanted organs, particularly with respect to rejection by the host immune system. Because transplanted organs have genomes that are distinct from the recipient's genome, we used high throughput shotgun sequencing to develop a universal noninvasive approach to monitoring organ health. We analyzed cell-free DNA circulating in the blood of heart transplant recipients...
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