Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids

Abstract excerpt

The recent development of 3D-liver stem cell cultures (hepatic organoids) opens up new avenues for gene and/or stem cell therapy to treat liver disease. To test safety and efficacy, a relevant large animal model is essential but not yet established. Because of its shared pathologies and disease pathways, the dog is considered the best model for human liver disease. Here we report the establishment of a long-term...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer Research and Treatments
• Share to Liver physiology and pathology
• Share to Organ Transplantation Techniques and Outcomes