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Article

ATP7B gene therapy of autologous reprogrammed hepatocytes alleviates copper accumulation in a mouse model of Wilson's disease.

Hepatology (Baltimore, Md.) - 1 Oct 2022

Cai Hongxia, Cheng Xing, Wang Xiao-Ping

Abstract excerpt

BACKGROUND AND AIMS: Wilson's disease (WD) is a rare hereditary disorder due to ATP7B gene mutation, causing pathologic copper storage mainly in the liver and neurological systems. Hepatocyte transplantation showed therapeutic potential; however, this strategy is often hindered by a shortage of quality donor cells and by allogeneic immune rejection. In this study, we aimed to evaluate the function and efficacy of...

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Identifiers

PMID: 35340061
DOI: 10.1002/hep.32484
PMCID: PMC9790736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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