Article
Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas.
International journal of epidemiology - 1 Feb 2016
Montazeri Zahra, Theodoratou Evropi, Nyiraneza Christine, Timofeeva Maria, Chen Wanjing, Svinti Victoria, Sivakumaran Shanya, Gresham Gillian, Cubitt Laura, Carvajal-Carmona Luis, Bertagnolli Monica M, Zauber Ann G, Tomlinson Ian, Farrington Susan M, Dunlop Malcolm G, Campbell Harry, Little Julian
Abstract excerpt
BACKGROUND: Low penetrance genetic variants, primarily single nucleotide polymorphisms, have substantial influence on colorectal cancer (CRC) susceptibility. Most CRCs develop from colorectal adenomas (CRA). Here we report the first comprehensive field synopsis that catalogues all genetic association studies on CRA, with a parallel online database [http://www.chs.med.ed.ac.uk/CRAgene/]. METHODS: We performed a...
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