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Article

High-grade B-cell Lymphoma With MYC Rearrangement and Without BCL2 and BCL6 Rearrangements Is Associated With High P53 Expression and a Poor Prognosis.

The American journal of surgical pathology - 1 Feb 2016

Li Shaoying, Weiss Vivian L, Wang Xuan J, Desai Parth A, Hu Shimin, Yin C Cameron, Tang Guilin, Reddy Nishitha M, Medeiros L Jeffrey, Lin Pei

Abstract excerpt

Patients with MYC/BCL2 double-hit lymphoma (DHL) are known to have an aggressive clinical course and to respond poorly to various therapies including intensive chemotherapy and stem cell transplant. Less is known about high-grade B-cell lymphoma with MYC rearrangement without concomitant BCL2 and BCL6 rearrangement, designated here as single-hit lymphoma (SHL). In this study, we assessed 61 cases of SHL and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-bcl-2

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Source

Identifiers

PMID: 26448193
DOI: 10.1097/PAS.0000000000000542

Genes

BCL2
MYC
BCL6
IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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