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Article

Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Oct 2015

Aller M Isabel, Pecoraro Valeria, Paternain Ana V, Canals Santiago, Lerma Juan

Abstract excerpt

The understanding of brain diseases requires the identification of the molecular, synaptic, and cellular disruptions underpinning the behavioral features that define the disease. The importance of genes related to synaptic function in brain disease has been implied in studies describing de novo germline mutations and copy number variants. Indeed, de novo copy number variations (deletion or duplication of a...

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Identifiers

PMID: 26446216
DOI: 10.1523/JNEUROSCI.2217-15.2015
PMCID: PMC6605382

Genes

GRIK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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