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Article

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.

Angiogenesis - 1 Jan 2016

Janssen Lauriane, Dupont Laura, Bekhouche Mourad, Noel Agnès, Leduc Cédric, Voz Marianne, Peers Bernard, Cataldo Didier, Apte Suneel S, Dubail Johanne, Colige Alain

Abstract excerpt

The only documented activity of a subclass of ADAMTS proteases comprising ADAMTS2, 3 and 14 is the cleavage of the aminopropeptide of fibrillar procollagens. A limited number of in vitro studies suggested that ADAMTS3 is mainly responsible for procollagen II processing in cartilage. Here, we created an ADAMTS3 knockout mouse (Adamts3(-/-)) model to determine in vivo the actual functions of ADAMTS3. Heterozygous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Embryo Loss

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Share to Neovascularization, Physiologic

Share to Vascular Endothelial Growth Factor C

Source

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Identifiers

PMID: 26446156
DOI: 10.1007/s10456-015-9488-z
PMCID: PMC4700087

Genes

ADAMTS3
ADAMTS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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