Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis

1 Jun 2020

Abstract excerpt

Proteolytical processing of the growth factor VEGFC through the concerted activity of CCBE1 and ADAMTS3 is required for lymphatic development to occur. How these factors act together in time and space, and which cell types produce these factors is not understood. Here we assess the function of Adamts3 and the related protease Adamts14 during zebrafish lymphangiogenesis and show both proteins to be able to process...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Developmental Biology and Gene Regulation
Share to Lymphatic System and Diseases
Share to Planarian Biology and Electrostimulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32483144
DOI: 10.1038/s41467-020-16552-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesisPMID 32483144Read ↗

Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFDSemantic proximity Read ↗

Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting.Semantic proximity Read ↗

Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesisSemantic proximity Read ↗

When form meets function: the cells and signals that shape the lymphatic vasculature during developmentSemantic proximity Read ↗

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.Semantic proximity Read ↗

Getting out and about: the emergence and morphogenesis of the vertebrate lymphatic vasculatureSemantic proximity Read ↗

mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish.Semantic proximity Read ↗

<i>CCBE1</i> Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C ActivationSemantic proximity Read ↗

Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration.Semantic proximity Read ↗

<i>lyve1</i> expression reveals novel lymphatic vessels and new mechanisms for lymphatic vessel development in zebrafishSemantic proximity Read ↗

A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.Semantic proximity Read ↗

Development of the Zebrafish Lymphatic System Requires Vegfc SignalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.