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The Link between Morphotype Transition and Virulence in Cryptococcus neoformans

21 Jun 2012

Abstract excerpt

Cryptococcus neoformans is a ubiquitous human fungal pathogen. This pathogen can undergo morphotype transition between the yeast and the filamentous form and such morphological transition has been implicated in virulence for decades. Morphotype transition is typically observed during mating, which is governed by pheromone signaling. Paradoxically, components specific to the pheromone signaling pathways play no or...

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PMID: 22737071
DOI: 10.1371/journal.ppat.1002765

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