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Morphology and its underlying genetic regulation impact the interaction between Cryptococcus neoformans and its hosts

3 Apr 2015

Abstract excerpt

Cryptococcus neoformans is a fungus that causes the majority of fatal cryptococcal meningitis cases worldwide. This pathogen is capable of assuming different morphotypes: yeast, pseudohypha, and hypha. The yeast form is the most common cell type observed clinically. The hyphal and pseudohyphal forms are rarely observed in the clinical setting and are considered attenuated in virulence. However, as a ubiquitous...

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PMID: 25841056
DOI: 10.1093/mmy/myv012

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