Methylation-mediated BMPER expression in fibroblast activation in vitro and lung fibrosis in mice in vivo

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease. Although the pathogenesis is poorly understood, evidence suggests that genetic and epigenetic alterations, such as DNA methylation, may play a key role. Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) superfamily and are important regulators in IPF. Here we identified BMP endothelial cell...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
• Share to Neonatal Respiratory Health Research
• Share to Pulmonary Hypertension Research and Treatments