Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Highlighting the problematic reliance on CD18 for diagnosing leukocyte adhesion deficiency type 1.

Immunologic research - 1 Apr 2016

Levy-Mendelovich Sarina, Rechavi Erez, Abuzaitoun Omar, Vernitsky Helly, Simon Amos J, Lev Atar, Somech Raz

Abstract excerpt

Leukocyte adhesion deficiency type 1 (LAD-1) is an autosomal recessive primary immunodeficiency, hallmarked by defective polymorphonuclear transmigration. It is caused by mutations in the gene encoding CD18, which interfere with the CD18/CD11 heterodimerization and expression on leukocyte cell surface. LAD-1 diagnosis rests primarily on the measurement of CD18 expression. However, CD18 measurement entails its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD18 Antigens
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunophenotyping

Share to Leukocyte-Adhesion Deficiency Syndrome

Share to Leukocyte Count

Share to Leukocytes

Share to Reproducibility of Results

Share to Transplantation, Homologous

Source

Identifiers

PMID: 26434744
DOI: 10.1007/s12026-015-8706-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Highlighting the problematic reliance on CD18 for diagnosing leukocyte adhesion deficiency type 1.PMID 26434744Read ↗

Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins.Semantic proximity Read ↗

Clinical and laboratory findings in patients with leukocyte adhesion deficiency type I: A multicenter study in Turkey.Semantic proximity Read ↗

A novel ITGB2 variant with long survival in patients with leukocyte adhesion defect type-I.Semantic proximity Read ↗

Characterization of four CD18 mutants in leucocyte adhesion deficient (LAD) patients with differential capacities to support expression and function of the CD11/CD18 integrins LFA-1, Mac-1 and p150,95.Semantic proximity Read ↗

Molecular characterization of leukocyte adhesion deficiency-I in Indian patients: identification of 9 novel mutations.Semantic proximity Read ↗

Rare and Heterogeneous manifestations of Leucocyte adhesion deficiency type 1: Report of two cases with diagnostic dilemmas and Novel ITGB mutation.Semantic proximity Read ↗

A novel point mutation in CD18 causing the expression of dysfunctional CD11/CD18 leucocyte integrins in a patient with leucocyte adhesion deficiency (LAD)Semantic proximity Read ↗

Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands.Semantic proximity Read ↗

Clinical and Genetic Spectrum of a Large Cohort of Patients With Leukocyte Adhesion Deficiency Type 1 and 3: A Multicentric Study From India.Semantic proximity Read ↗

A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1.Semantic proximity Read ↗

β2 Integrins—Multi-Functional Leukocyte Receptors in Health and DiseaseSemantic proximity Read ↗

Characterization of two new CD18 alleles causing severe leukocyte adhesion deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.