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Clinical and laboratory findings in patients with leukocyte adhesion deficiency type I: A multicenter study in Turkey.

Clinical and experimental immunology - 1 Oct 2021

Yaz Ismail, Ozbek Begum, Bildik Hacer Neslihan, Tan Cagman, Oskay Halacli Sevil, Soyak Aytekin Elif, Esenboga Saliha, Cekic Sukru, Kilic Sara Sebnem, Keskin Ozlem, van Leeuwen Karin, Roos Dirk, Cagdas Deniz, Tezcan Ilhan

Abstract excerpt

Leukocyte adhesion deficiency type I is a rare primary immunodeficiency disorder characterized by mutations in the ITGB2 gene encoding CD18. We present clinical and immunological features of 15 patients with leukocyte adhesion deficiency type 1 (LAD-1). Targeted next-generation sequencing was performed with either a primary immunodeficiency gene panel comprising 266 genes or a small LAD-panel consisting of five...

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Identifiers

PMID: 34310689
DOI: 10.1111/cei.13645
PMCID: PMC8446394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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