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Article

A novel ITGB2 variant with long survival in patients with leukocyte adhesion defect type-I.

Immunologic research - 1 Oct 2021

Celiksoy Mehmet Halil, Köker Mustafa Yavuz, Gezdirici Alper, Ozsoy Sevil, Malbora Baris, Gungor Songul

Abstract excerpt

Leukocyte adhesion deficiency is an autosomal recessive primary immunodeficiency that has been divided into three types: LAD1 (beta-2 integrin (CD18) family deficiency/defect), LAD2 (absence of fucosylated carbonhydrate ligands for selectins) and LAD3 (defective activation of all beta integrins). However, recently LAD4 has been described in cystic fibrosis patients, with a defect in integrin activation reported...

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Source

Identifiers

PMID: 34333755
DOI: 10.1007/s12026-021-09222-3

Genes

ITGB2
LAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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