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Methotrexate and Pralatrexate

1 Aug 2015

Abstract excerpt

This article reviews methotrexate and the more potent, related compound, pralatrexate, for the treatment of cutaneous T-cell lymphomas, including mycosis fungoides, Sézary syndrome, and CD30+ lymphoproliferative disorders. Although these folate antagonists are traditionally viewed as antiproliferative cell cycle inhibitors, it is recognized that they inhibit DNA methylation, providing a rationale for their use as...

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PMID: 26433846
DOI: 10.1016/j.det.2015.05.009

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