Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mathematical modeling of folate metabolism.

Wiley interdisciplinary reviews. Systems biology and medicine - 1 Jan 2000

Panetta John C, Paugh Steven W, Evans William E

Abstract excerpt

Folate metabolism is a complex biological process that is influenced by many variables including transporters, cofactors, and enzymes. Mathematical models provide a useful tool to evaluate this complex system and to elucidate hypotheses that would be otherwise untenable to test in vitro or in vivo. Forty years of model development and refinement along with enhancements in technology have led to systematic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Models, Theoretical
Share to Folic Acid
Share to Methotrexate

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to ATP-Binding Cassette Transporters

Share to Drug Interactions

Share to Multidrug Resistance-Associated Proteins

Share to Peptide Synthases

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed Open full text

Identifiers

PMID: 23703958
DOI: 10.1002/wsbm.1227
PMCID: PMC3745816

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mathematical modeling of folate metabolism.PMID 23703958Read ↗

Computational modelling folate metabolism and DNA methylation: implications for understanding health and ageingSemantic proximity Read ↗

Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis.Semantic proximity Read ↗

Modeling folate, one-carbon metabolism, and DNA methylationSemantic proximity Read ↗

Human reduced folate carrier: translation of basic biology to cancer etiology and therapySemantic proximity Read ↗

Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissuesSemantic proximity Read ↗

Reduced folate carrier: biochemistry and molecular biology of the normal and methotrexate-resistant cell.Semantic proximity Read ↗

Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of actionSemantic proximity Read ↗

Folate transporter dynamics and therapy with classic and tumor-targeted antifolatesSemantic proximity Read ↗

Unveiling the Therapeutic Potential of Folate-Dependent One-Carbon Metabolism in Cancer and NeurodegenerationSemantic proximity Read ↗

Characterization of soluble folate receptors (folate binding proteins) in humans. Biological roles and clinical potentials in infection and malignancySemantic proximity Read ↗

Cell cycle regulation of folate‐mediated one‐carbon metabolismSemantic proximity Read ↗

Folic AcidSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.