Methotrexate

Abstract excerpt

Previously established as a chemotherapeutic agent for decades, methotrexate has been adapted for use as a medical therapy for unruptured ectopic pregnancies. Its mechanism of action, competitive inhibition of folate-dependent steps in nucleic acid synthesis, effectively kills the rapidly dividing ectopic trophoblast. However, the same action on normal cells is the basis for many of its adverse effects.

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• Share to Ectopic Pregnancy Diagnosis and Management
• Share to Gestational Trophoblastic Disease Studies
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