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Serum-free process development: improving the yield and consistency of human mesenchymal stromal cell production

29 Sept 2015

Abstract excerpt

BACKGROUND AIMS: The cost-effective production of human mesenchymal stromal cells (hMSCs) for off-the-shelf and patient specific therapies will require an increasing focus on improving product yield and driving manufacturing consistency. METHODS: Bone marrow-derived hMSCs (BM-hMSCs) from two donors were expanded for 36 days in monolayer with medium supplemented with either fetal bovine serum (FBS) or PRIME-XV...

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PMID: 26432558
DOI: 10.1016/j.jcyt.2015.08.002

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