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Article

Imaging Reporters for Proteasome Activity Identify Tumor- and Metastasis-Initiating Cells.

Molecular imaging - 1 Jan 2015

Stacer Amanda C, Wang Hanxiao, Fenner Joseph, Dosch Joseph S, Salomonnson Anna, Luker Kathryn E, Luker Gary D, Rehemtulla Alnawaz, Ross Brian D

Abstract excerpt

Tumor-initiating cells, also designated as cancer stem cells, are proposed to constitute a subpopulation of malignant cells central to tumorigenesis, metastasis, and treatment resistance. We analyzed the activity of the proteasome, the primary organelle for targeted protein degradation, as a marker of tumor- and metastasis-initiating cells. Using human and mouse breast cancer cells expressing a validated...

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Identifiers

PMID: 26431589
PMCID: PMC4663702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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