Article
In vivo imaging, tracking, and targeting of cancer stem cells.
Journal of the National Cancer Institute - 4 Mar 2009
Vlashi Erina, Kim Kwanghee, Lagadec Chann, Donna Lorenza Della, McDonald John Tyson, Eghbali Mansoureh, Sayre James W, Stefani Encrico, McBride William, Pajonk Frank
Abstract excerpt
BACKGROUND: There is increasing evidence that solid cancers contain cancer-initiating cells (CICs) that are capable of regenerating a tumor that has been surgically removed and/or treated with chemotherapy and/or radiation therapy. Currently, cell surface markers, like CD133 or CD44, are used to identify CICs in vitro; however, these markers cannot be used to identify and track CICs in vivo. The 26S proteasome is...
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