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Article

Bortezomib enhances expression of effector molecules in anti-tumor CD8+ T lymphocytes by promoting Notch-nuclear factor-κB crosstalk.

Oncotarget - 20 Oct 2015

Thounaojam Menaka C, Dudimah Duafalia F, Pellom Samuel T, Uzhachenko Roman V, Carbone David P, Dikov Mikhail M, Shanker Anil

Abstract excerpt

The immunosuppressive tumor microenvironment usurps host antitumor immunity by multiple mechanisms including interference with the Notch system, which is important for various metazoan cell fate decisions and hematopoietic cell differentiation and function. We observed that treatment with the proteasome inhibitor bortezomib in mice bearing various solid tumors resulted in an upregulated expression of various...

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Identifiers

PMID: 26431276
DOI: 10.18632/oncotarget.5857
PMCID: PMC4741704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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