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Article

A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer.

Oncotarget - 27 Oct 2015

Richards Edward J, Permuth-Wey Jennifer, Li Yajuan, Chen Y Ann, Coppola Domenico, Reid Brett M, Lin Hui-Yi, Teer Jamie K, Berchuck Andrew, Birrer Michael J, Lawrenson Kate, Monteiro Alvaro N A, Schildkraut Joellen M, Goode Ellen L, Gayther Simon A, Sellers Thomas A, Cheng Jin Q

Abstract excerpt

The homeobox A (HOXA) region of protein-coding genes impacts female reproductive system embryogenesis and ovarian carcinogenesis. The 5-prime end of HOXA includes three long non-coding RNAs (lncRNAs) (HOXA10-AS, HOXA11-AS, and HOTTIP) that are underexplored in epithelial ovarian cancer (EOC). We evaluated whether common genetic variants in these lncRNAs are associated with EOC risk and/or have functional roles in...

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Source

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Identifiers

PMID: 26430965
DOI: 10.18632/oncotarget.5784
PMCID: PMC4741487

Genes

HOXA11
HOXA10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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