Article
Genetic variants in lncRNA HOTAIR are associated with risk of colorectal cancer.
Mutagenesis - 1 Mar 2015
Xue Yao, Gu Dongying, Ma Gaoxiang, Zhu Lingjun, Hua Qiuhan, Chu Haiyan, Tong Na, Chen Jinfei, Zhang Zhengdong, Wang Meilin
Abstract excerpt
Long non-coding RNA HOX transcript antisenseRNA (HOTAIR) has been widely identified to participate in tumour pathogenesis, acting as a promoter in colorectal cancer carcinogenesis. However, the association between genetic variants in HOTAIR and cancer risk has not yet been reported. In the present study, we performed a two-stage case-control study to investigate the association between HOTAIR tagSNPs and the risk...
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