Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients.

doi:10.1158/1078-0432.CCR-15-0357

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Article

Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2015

Kurose Koji, Ohue Yoshihiro, Wada Hisashi, Iida Shinsuke, Ishida Takashi, Kojima Takashi, Doi Toshihiko, Suzuki Susumu, Isobe Midori, Funakoshi Takeru, Kakimi Kazuhiro, Nishikawa Hiroyoshi, Udono Heiichiro, Oka Mikio, Ueda Ryuzo, Nakayama Eiichi

Abstract excerpt

PURPOSE: FoxP3(+) Tregs inhibit immune responses against tumors. KW-0761 is a humanized anti-human CCR4 monoclonal antibody (mAb) that has antibody-dependent cellular cytotoxicity activity. Depletion of CCR4-expressing FoxP3(+) CD4 Tregs by KW-0761 infusion was investigated in solid cancer patients. EXPERIMENTAL DESIGN: We conducted a phase Ia clinical trial of KW-0761 infusion in 7 lung and 3 esophageal cancer...

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Identifiers

PMID: 26429981
DOI: 10.1158/1078-0432.CCR-15-0357

Genes

CCR4

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