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Article

Performance of PCR-reverse blot hybridization assay for detection of rifampicin-resistant Mycobacterium leprae.

Journal of microbiology (Seoul, Korea) - 1 Oct 2015

Wang Hye-young, Kim Hyunjung, Kim Yeun, Bang Hyeeun, Kim Jong-Pill, Hwang Joo Hwan, Cho Sang-Nae, Kim Tae Ue, Lee Hyeyoung

Abstract excerpt

Drug resistance in Mycobacterium leprae is a significant problem in countries where leprosy is endemic. A sensitive, specific, and high-throughput reverse blot hybridization assay (REBA) for the detection of genotypic resistance to rifampicin (RIF) was designed and evaluated. It has been shown that resistance to RIF in M. leprae involves mutations in the rpoB gene encoding the -subunit of the RNA polymerase. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26428919
DOI: 10.1007/s12275-015-5057-9

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